Interdiction of hypoglycemia in diabetic children by multiparticulate dosage form with controlled glucose release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10301798" target="_blank" >RIV/00179906:_____/16:10301798 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/16:43874274
Result on the web
<a href="http://dx.doi.org/10.3109/10837450.2015.1073741" target="_blank" >http://dx.doi.org/10.3109/10837450.2015.1073741</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2015.1073741" target="_blank" >10.3109/10837450.2015.1073741</a>
Alternative languages
Result language
angličtina
Original language name
Interdiction of hypoglycemia in diabetic children by multiparticulate dosage form with controlled glucose release
Original language description
Patients tend to evade the occurrence of hypoglycemic episodes by excessive carbohydrate intake. Glucose pellets with delayed release in the time of the maximum effect of insulin can not only prevent hypoglycemia but also eliminate the preventive carbohydrate intake. The pellets can be administered in a mixture with semisolid food. The cores containing glucose in combination with osmotically active agents (croscarmellose sodium, carmellose sodium, polyethylene glycol, or carboxymethyl starch) were prepared by extrusion-spheronization and coated with 15% water ethylcellulose dispersion (Surelease BNF) in Wurster column (Medipo, Havlíčkův Brod, Czech Republic) into four coating levels (12.5, 25, 35, and 50%). Mean particle size is 0.63-0.73 for cores and 0.82-0.98 for coated pellets. Cores and coated pellets have excellent or good flow properties according to Hausner ratio and Carr index. Aspect ratio ranges from 1.78 to 2.17 for cores and from 1.73 to 2.31 for coated pellets. Dissolution was performed using pH-independent method and method with continual change of pH. The suitable pH-independent release was achieved in the samples containing carboxymethyl starch or polyethylene glycol. Glucose release is enabled by a membrane rupture caused by core swelling. It can be, therefore, assumed that the glucose release profile will not be affected by food or transit time.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14479" target="_blank" >NT14479: Preparation of dosage forms with controlled release of glucose to prevention of hypoglycemic states.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical Development and Technology
ISSN
1083-7450
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
867-874
UT code for WoS article
000388621500010
EID of the result in the Scopus database
2-s2.0-84940776431