Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10332545" target="_blank" >RIV/00179906:_____/16:10332545 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/16:43874281

Result on the web

<a href="http://dx.doi.org/10.1515/acph-2016-0017" target="_blank" >http://dx.doi.org/10.1515/acph-2016-0017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/acph-2016-0017" target="_blank" >10.1515/acph-2016-0017</a>

Result language

angličtina

Original language name

Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes

Original language description

Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120-360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The pellets contain glucose in combination with an osmotically active ingredient and are coated with an ethylcellulose dispersion, which forms an insoluble semipermeable membrane and ensures delayed release. The release of glucose was assessed using dissolution and high-performance liquid chromatography. Dissolution profiles indicated the possibility of achieving the requested lag time using a combination of adequate compositions and coating concentrations. Lag times of 60, 240 and 360 min were achieved. The sample containing carboxymethyl starch was found to be most suitable for the intent of this work.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

—

Project

<a href="/en/project/NT14479" target="_blank" >NT14479: Preparation of dosage forms with controlled release of glucose to prevention of hypoglycemic states.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Pharmaceutica

ISSN

1330-0075

e-ISSN

—

Volume of the periodical

66

Issue of the periodical within the volume

2

Country of publishing house

HR - CROATIA

Number of pages

11

Pages from-to

257-267

UT code for WoS article

000377425200008

EID of the result in the Scopus database

2-s2.0-84974676860