Baseline serum levels of multiple cytokines and adhesion molecules in patients with acute myeloid leukemia: results of a pivotal trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10288714" target="_blank" >RIV/00179906:_____/14:10288714 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/14:43875255 RIV/00216208:11150/14:10288714

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Baseline serum levels of multiple cytokines and adhesion molecules in patients with acute myeloid leukemia: results of a pivotal trial

Original language description

Evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients with newly diagnosed acute myeloid leukemia (AML) using biochip array technology. We searched for links between baseline levels and age, hyperleukocytosis, secondary origin of AML, resistance to induction therapy with cytarabine and daunorubicin and standard risk stratification according to cytogenetics and molecular genetics. Methods: We evaluated the sera of 51 consecutive patients. Serum samples were analyzed by biochip based immunoassays on the Evidence Investigator analyzer. T-tests were used for statistical analysis. Results: We found that higher age is associated with lower levels of interleukin (IL)-12. Patients with secondary disease were older, had higher levels of EGF and IL-7, and lower levels of E-selectin, IL-12 and IL-13. In hyperleukocytosis, the levels of IL-1?, IL-2, TNF-?, VCAM-1, ICAM-1, E-selectin and L-selectin were increased, whereas levels of IFN-? and MCP-1 were decreased. In patien

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Oncology

ISSN

1812-9269

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

4

Country of publishing house

UA - UKRAINE

Number of pages

6

Pages from-to

252-257

UT code for WoS article

—

EID of the result in the Scopus database

—