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Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10289032" target="_blank" >RIV/00179906:_____/14:10289032 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14740/14:00077330 RIV/65269705:_____/14:00061517 RIV/00159816:_____/14:00061517 RIV/61989592:15110/14:33150927

  • Result on the web

    <a href="http://dx.doi.org/10.1093/carcin/bgu212" target="_blank" >http://dx.doi.org/10.1093/carcin/bgu212</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/carcin/bgu212" target="_blank" >10.1093/carcin/bgu212</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

  • Original language description

    Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification ofsix-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). O(6)-methylguanine-DNA

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Carcinogenesis

  • ISSN

    0143-3334

  • e-ISSN

  • Volume of the periodical

    35

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    2756-2762

  • UT code for WoS article

    000345836200015

  • EID of the result in the Scopus database