Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10289032" target="_blank" >RIV/00179906:_____/14:10289032 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/14:00077330 RIV/65269705:_____/14:00061517 RIV/00159816:_____/14:00061517 RIV/61989592:15110/14:33150927
Result on the web
<a href="http://dx.doi.org/10.1093/carcin/bgu212" target="_blank" >http://dx.doi.org/10.1093/carcin/bgu212</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/carcin/bgu212" target="_blank" >10.1093/carcin/bgu212</a>

Result language
angličtina
Original language name
Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients
Original language description
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification ofsix-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). O(6)-methylguanine-DNA
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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