Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F14%3A00080042" target="_blank" >RIV/00209805:_____/14:00080042 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/14:00077330 RIV/65269705:_____/14:00061517 RIV/00179906:_____/14:10289032 RIV/00159816:_____/14:00061517 RIV/61989592:15110/14:33150927
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/25322872/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/25322872/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/carcin/bgu212" target="_blank" >10.1093/carcin/bgu212</a>
Alternative languages
Result language
angličtina
Original language name
Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients
Original language description
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification of six-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). O(6)-methylguanine-DNA methyltransferase methylation status was evaluated as reference method and Risk Score based on six-miRNA signature indicated significant superiority in prediction of clinical outcome in GBM patients. Multivariate Cox analysis indicated that the Risk Score based on six-miRNA signature is an independent prognostic classifier of GBM patients. We suggest that the Risk Score presents promising prognostic algorithm with potential for individualized treatment decisions in clinical management of GBM patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/NT11214" target="_blank" >NT11214: Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carcinogenesis
ISSN
0143-3334
e-ISSN
1460-2180
Volume of the periodical
35
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
2756-62
UT code for WoS article
000345836200015
EID of the result in the Scopus database
2-s2.0-84923532167