Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10325088" target="_blank" >RIV/00179906:_____/16:10325088 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/16:10325088
Result on the web
<a href="http://link.springer.com/article/10.1007/s00296-016-3552-x/fulltext.html" target="_blank" >http://link.springer.com/article/10.1007/s00296-016-3552-x/fulltext.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00296-016-3552-x" target="_blank" >10.1007/s00296-016-3552-x</a>
Alternative languages
Result language
angličtina
Original language name
Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis
Original language description
The goal of this prospective study was to assess non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy in patients with rheumatoid arthritis (RA) or osteoarthritis (OA) by means of non-invasive wireless capsule enteroscopy. A total of 143 patients (74 with RA, 69 with OA) treated with NSAIDs (>1 month) and 42 healthy volunteers were included. All subjects underwent capsule endoscopy, laboratory tests and filled in questionnaires. The severity of small bowel injury was graded as: mild (red spots or sporadic erosions), moderate (10-20 erosions) or severe (>20 erosions or ulcers). Capsule endoscopy identified small bowel lesions in 44.8 % of patients (mild 36.4 %, moderate 3.5 % and severe in 4.9 %). Mild non-specific lesions were found in 11.9 % healthy volunteers. There was a significantly higher prevalence of enteropathy in RA (56.8 %) compared to OA (31.9 %, p < 0.01). A significant difference between NSAID users (RA and OA) with and without enteropathy was observed in erythrocytes (p < 0.01), the leucocyte count (p < 0.05), haemoglobin (p < 0.05), haematocrit (p < 0.05), serum albumin (p < 0.01) and erythrocyte sedimentation rate (p < 0.05). No relationship was found between enteropathy and dyspepsia, gender or age. NSAID therapy is associated with a significant risk of small bowel injury. The risk is significantly higher in RA patients suggesting a possible influence of the underlying disease.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Rheumatology International
ISSN
0172-8172
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
1557-1561
UT code for WoS article
000385246000009
EID of the result in the Scopus database
2-s2.0-84983559752