Anti-Outer membrane protein C antibodies in colorectal neoplasia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10332323" target="_blank" >RIV/00179906:_____/16:10332323 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/16:10332323
Result on the web
<a href="http://dx.doi.org/10.1007/s12223-015-0437-4" target="_blank" >http://dx.doi.org/10.1007/s12223-015-0437-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12223-015-0437-4" target="_blank" >10.1007/s12223-015-0437-4</a>
Alternative languages
Result language
angličtina
Original language name
Anti-Outer membrane protein C antibodies in colorectal neoplasia
Original language description
Sporadic colorectal cancer (CRC) represents an enormous problem worldwide. Large intestinal microbiota play an important role in the colorectal carcinogenesis. The aim of the study was to investigate anti-Outer membrane protein C (anti-OmpC) antibodies, aimed at porin C, which is embedded in the outer membrane of gram-negative bacteria, in patients with colorectal adenoma (CRA), CRC and controls. The study included 22 patients with CRA (11 men, 11 women, aged 26-79, mean 65 +/- 12), 11 patients with CRC (9 men, 2 women, aged 50-83, mean 66 +/- 11) and 45 controls, blood donors (24 men, 21 women, aged 20-58, mean 38 +/- 10). Serum anti-OmpC antibodies were investigated by means of ELISA. Values of 0-20 U/mL were considered to be negative; values > 25 U/mL were assessed as positive. A total of 9/11 (82 %) patients with CRC had positive anti-OmpC antibodies. Anti-OmpC antibodies were negative or grey-zone in 37/45 (82 %) controls. Serum anti-OmpC were found to be significantly higher in patients with CRC (median 42.4, interquartile range (IQR) 22.2) compared to controls (median 18.3, IQR 12.4), p < 0.001. No statistically significant difference in anti-OmpC was found between controls (median 18.3, IQR 12.4) and CRA patients (median 17.7, IQR 16.5), p=0.326. Anti-OmpC were significantly higher in patients with CRC (median 42.4, IQR 22.2) compared to patients with CRA (median 17.7, IQR 16.5), p=0.011. Positivity of anti-OmpC antibodies was found in patients with CRC, which supports the contribution of gram-negative large intestinal microbiota to the pathogenesis of CRC.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13413" target="_blank" >NT13413: Determination of apoptosis in the bioptic samples taken from the colon</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Folia Microbiologica
ISSN
0015-5632
e-ISSN
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Volume of the periodical
61
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
295-299
UT code for WoS article
000381765900004
EID of the result in the Scopus database
2-s2.0-84948442168