Serum S100A6, S100A8, S100A9 and S100A11 proteins in colorectal neoplasia: results of a single centre prospective study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F20%3A10407149" target="_blank" >RIV/00216208:11150/20:10407149 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/20:10407149

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WodGc-JQSZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WodGc-JQSZ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00365513.2019.1704050" target="_blank" >10.1080/00365513.2019.1704050</a>

Result language

angličtina

Original language name

Serum S100A6, S100A8, S100A9 and S100A11 proteins in colorectal neoplasia: results of a single centre prospective study

Original language description

S100 proteins are involved in biological events related to colorectal carcinogenesis. Aim of this prospective study was to assess serum concentration of S100A6, A8, A9 and A11 proteins in patients with colorectal neoplasia. Eighty-four subjects were enrolled: 20 controls (average risk population with normal findings on colonoscopy; 7 men, 13 women, age 23-74, mean 55 +/- 14), 20 patients with non-advanced colorectal adenoma (non-AA, 10 men, 10 women, age 41-82, mean 62 +/- 11), 22 with advanced colorectal adenoma (AA, 15 men, 7 women, age 49-80, mean 64 +/- 8) and 22 with colorectal cancer (CRC, 12 men, 10 women, age 49-86, mean 69 +/- 10). Peripheral venous blood was obtained. Serum S100 proteins were investigated by enzyme immunoassay technique. Serum S100A6 was significantly lower in CRC (mean 8530 +/- 4743 ng/L), p = .035 compared to controls (mean 11308 +/- 2968 ng/L). Serum S100A8 was significantly higher in AA (median 11955 ng/L, IQR 2681-34756 ng/L), p = .009 and in CRC (median 27532 ng/L, IQR 6794-35092 ng/L), p &lt; .001 compared to controls (median 2513 ng/L, IQR 2111-4881 ng/L). Serum S100A9 concentrations did not differ between any tested group and controls, p &gt; .05. Serum concentration of S100A11 was significantly lower in non-AA (mean 3.5 +/- 2.4 mu g/L), p = .004 and in CRC (mean 3.4 +/- 2.4 mu g/L), p = .002 compared to controls (mean 5.9 +/- 2.5 mu g/L). Sensitivity and specificity for S100A8 protein in patients with CRC were 94% and 73%; positive predictive value 68% and negative predictive value 95%. Patients with colorectal neoplasia have significantly lower serum S100A6 and S100A11 levels, significantly higher S100A8 and unaltered serum S100A9 levels.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scandinavian Journal of Clinical and Laboratory Investigation

ISSN

0036-5513

e-ISSN

—

Volume of the periodical

80

Issue of the periodical within the volume

3

Country of publishing house

NO - NORWAY

Number of pages

6

Pages from-to

173-178

UT code for WoS article

000503604700001

EID of the result in the Scopus database

2-s2.0-85076916153