Umbilical cord blood markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10333015" target="_blank" >RIV/00179906:_____/16:10333015 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/16:10333015

Result on the web

<a href="http://dx.doi.org/10.3109/14767058.2015.1074997" target="_blank" >http://dx.doi.org/10.3109/14767058.2015.1074997</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/14767058.2015.1074997" target="_blank" >10.3109/14767058.2015.1074997</a>

Result language

angličtina

Original language name

Umbilical cord blood markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes

Original language description

Objective: To determine umbilical cord blood total antioxidant capacity (TAC), ferric reducing antioxidant power (FRAP), thiobarbituric acid-reacting substances (TBARS), advanced glycation end products (AGEs) and markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and their associations with microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA), funisitis and selected aspects of short-term neonatal morbidity.Materials and methods: One hundred and sixty-five women with singleton pregnancies complicated by PPROM were included in this study. Blood samples were obtained by venipuncture from the umbilical cord vein after the delivery of the newborn. The umbilical cord blood concentrations of TAC, FRAP, TBARS and AGEs were measured.Results: The presence of MIAC, HCA and funisitis did not show differences in the umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations. Positive correlations were found between the gestational age at sampling and umbilical cord blood TAC and AGEs concentrations (TAC: rho=0.26; p=0.001; AGEs: rho=0.35; p<0.0001). There was no association between umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations and selected aspects of short-term neonatal morbidity.Conclusions: Oxidative stress is associated with PPROM, as indicated by the presence of markers tested in the umbilical cord blood; however, the evaluated oxidative stress markers are not influenced by the presence of MIAC and/or HCA, and funisitis or subsequent development of selected aspects of short-term neonatal morbidity.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

—

Project

<a href="/en/project/NT13461" target="_blank" >NT13461: The relationship between bacterial load in amniotic fluid and the intensity of intraamniotic inflammatory response in women with preterm prelabor rupture of membranes</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The Journal of Maternal-Fetal &amp; Neonatal Medicine

ISSN

1476-7058

e-ISSN

—

Volume of the periodical

29

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1900-1910

UT code for WoS article

000373516000005

EID of the result in the Scopus database

2-s2.0-84940099454