Tetroxime: reactivation potency - in vitro and in silico study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F17%3A10337258" target="_blank" >RIV/00179906:_____/17:10337258 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/17:43875727 RIV/62690094:18470/17:50005169
Result on the web
<a href="http://dx.doi.org/10.1039/c6ra16499d" target="_blank" >http://dx.doi.org/10.1039/c6ra16499d</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c6ra16499d" target="_blank" >10.1039/c6ra16499d</a>
Alternative languages
Result language
angličtina
Original language name
Tetroxime: reactivation potency - in vitro and in silico study
Original language description
Acetylcholinesterase (AChE) reactivators (oximes) are generally used as treatment in cases of nerve agent poisoning. There is no single oxime applicable in every case of nerve agent intoxication. Based on this fact, novel candidates with broader efficacy are still being sought. In this study, tetroxime a bisquaternary compound bearing four oxime groups, was evaluated for its potency to reactivate rat brain AChE inhibited by selected nerve agents (tabun, sarin, cyclosarin and VX agent). Despite the fact that this oxime contains four oxime groups that could be plausibly responsible for reactivation, it did not achieve broader reactivation activity. Satisfactory results were obtained only in the case of VX agent-inhibited AChE. In the cases of sarin-and cyclosarin-inhibited AChE, acceptable results were reached at higher oxime concentration only. Tetroxime was unable to reactivate tabun-inhibited AChE. However, compared with the gold standard pralidoxime, this oxime achieved more promising results.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GA15-16701S" target="_blank" >GA15-16701S: Concept of non-quaternary reactivators AChE as the antidotes of organophsophorus poisoning - a new hope or a blind way?</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RSC Advances
ISSN
2046-2069
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
7041-7045
UT code for WoS article
000393756000030
EID of the result in the Scopus database
2-s2.0-85010450466