A Comparison of the Ability of a New Bispyridinium Oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane Dibromide and Currently used Oximes to Reactivate Nerve Agent-inhibited Rat Brain Acetylcholinesterase by In Vitro Methods

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F03%3A00000902" target="_blank" >RIV/60162694:G16__/03:00000902 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G38__/03:00000902
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A Comparison of the Ability of a New Bispyridinium Oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane Dibromide and Currently used Oximes to Reactivate Nerve Agent-inhibited Rat Brain Acetylcholinesterase by In Vitro Methods
Original language description
The efficacy of a new bispyridinium oxime 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide, called K048, and currently used oximes (pralidoxime, obidoxime, the oxime HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. The new oxime K048 was found to be more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than pralidoxime (in the case of VX, tabun and cyclosarin), obidoxime (in the case of cyclosarin and tabun) and HI-6 (in the case of tabun) but it did not reach the efficacy of currently used oximes in the case of the inhibition of acetylcholinesterase by sarin. Thus, the oxime K048 seems to be relatively efficaciousbroad spectrum acetylcholinesterase reactivator and, therefore, it could be useful for the treatment of nerve agent-exposed people if information about detection of type of nerve agent is absent.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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