A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001312" target="_blank" >RIV/60162694:G44__/05:00001312 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods
Original language description
The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. Both H oximes (HLö-7, HI-6) werefound to be more efficacious reactivators of sarin and VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and does not reach the reactivating efficacy of obidoxime. In the case of cyclosarin, the oxime HI-6 was only found to be able sufficiently reactivate cyclosarin-inhibited acetylcholinesterase in vitro.Thus, the oxime HLö-7 does not seem to be more efficacious reactivator of nerve agent- inhibited acetylcholinesterase than HI-6 according to in vitro evaluation of their reactivation potency and, therefore, it is not more suitable to be introduced for antidotal treatment of nerve agent-exposed people than HI-6.
Czech name
Srovnávání schopnosti oximu Hlo-7 a současně užívaných oximů (HI-6, pralidoxim, obidoxim) reaktivovat in vitro potkaní acetylcholinesterázu inhibovanou NPL
Czech description
Srovnávání schopnosti oximu Hlo-7 a současně užívaných oximů (HI-6, pralidoxim, obidoxim) reaktivovat in vitro potkaní acetylcholinesterázu inhibovanou NPL.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Medica (Hradec Králové)
ISSN
1211-4286
e-ISSN
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Volume of the periodical
48
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
81-86
UT code for WoS article
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EID of the result in the Scopus database
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