In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6 and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001493" target="_blank" >RIV/60162694:G44__/06:00001493 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6 and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase
Original language description
The efficacy of H oximes (HI-6, HLö-7), the oxime BI-6 and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate acetylcholinesterase inhibited by two nerve agents (tabun, VX agent) was tested by in vitro methods. Both H oximes (HI-6,HLö-7) as well as the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and doesnot reach the reactivating efficacy of trimedoxime and obidoxime. Thus, none of them can be considered to be a broad spectrum reactivator of nerve agent-inhibited acetylcholinesterase in spite of their high potency to reactivate acetylcholinesterase inhibited by some nerve agents. Therefore, more than one oxime should be introduced for the antidotal treatment of nerve agent-exposed people.
Czech name
In vitro schopnost H oximů (HI-6, Hlo-7), oximu BI-6 a v současnosti užívaných oximů (pralidoxim, obidoxim, trimedoxim) reaktivovat acetylcholinesterázu inhibovanou NPL
Czech description
Byla testována schopnost H oximů (HI-6, Hlo-7), oximu BI-6 a v soucasnosti užívaných reaktivátorů AChE (pralidoxim, obidoxim, trimedoxim) reaktivova AChE inhibovanou nervově paralytickými látkami tabun a VX.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Toxicology and Environmental Health
ISSN
0098-4108
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1431-1440
UT code for WoS article
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EID of the result in the Scopus database
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