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Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives

Result description

In this study, a series of newly synthesized acridine derivatives, compounds 4, 6a, and 6b, are described and their biological activity on HL-60 cell lines is assessed using a number of different techniques. Binding studies were also performed between the derivatives and DNA in order to characterize the mechanism of the agents' effect in more detail. The results of ultraviolet-visible absorption spectroscopy prove that the binding of derivatives 4, 6a, and 6b had occurred with a binding constant value of K = 3.5 x 104 -4.0 x 104 M-1. These findings are indicative of a strong interaction between the derivatives and DNA, and this hypothesis is supported by the results of the fluorescence emission, linear dichroism, and viscometric assays.

Keywords

DNA bindingHL-60 cellsTopoisomerases I and IIAcridine derivatives

The result's identifiers

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives

  • Original language description

    In this study, a series of newly synthesized acridine derivatives, compounds 4, 6a, and 6b, are described and their biological activity on HL-60 cell lines is assessed using a number of different techniques. Binding studies were also performed between the derivatives and DNA in order to characterize the mechanism of the agents' effect in more detail. The results of ultraviolet-visible absorption spectroscopy prove that the binding of derivatives 4, 6a, and 6b had occurred with a binding constant value of K = 3.5 x 104 -4.0 x 104 M-1. These findings are indicative of a strong interaction between the derivatives and DNA, and this hypothesis is supported by the results of the fluorescence emission, linear dichroism, and viscometric assays.

  • Czech name

  • Czech description

Classification

  • Type

    Jimp - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Medicinal Chemistry Research

  • ISSN

    1054-2523

  • e-ISSN

  • Volume of the periodical

    26

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    2309-2321

  • UT code for WoS article

    000412416600008

  • EID of the result in the Scopus database

    2-s2.0-85020667695

Basic information

Result type

Jimp - Article in a specialist periodical, which is included in the Web of Science database

Jimp

OECD FORD

Pharmacology and pharmacy

Year of implementation

2017