Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F17%3A10363738" target="_blank" >RIV/00179906:_____/17:10363738 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00044-017-1931-9" target="_blank" >http://dx.doi.org/10.1007/s00044-017-1931-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00044-017-1931-9" target="_blank" >10.1007/s00044-017-1931-9</a>

Result language

angličtina

Original language name

Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives

Original language description

In this study, a series of newly synthesized acridine derivatives, compounds 4, 6a, and 6b, are described and their biological activity on HL-60 cell lines is assessed using a number of different techniques. Binding studies were also performed between the derivatives and DNA in order to characterize the mechanism of the agents&apos; effect in more detail. The results of ultraviolet-visible absorption spectroscopy prove that the binding of derivatives 4, 6a, and 6b had occurred with a binding constant value of K = 3.5 x 104 -4.0 x 104 M-1. These findings are indicative of a strong interaction between the derivatives and DNA, and this hypothesis is supported by the results of the fluorescence emission, linear dichroism, and viscometric assays.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicinal Chemistry Research

ISSN

1054-2523

e-ISSN

—

Volume of the periodical

26

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

2309-2321

UT code for WoS article

000412416600008

EID of the result in the Scopus database

2-s2.0-85020667695