Substituted piperazines as novel potential radioprotective agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F20%3A10409753" target="_blank" >RIV/00179906:_____/20:10409753 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/20:10409753 RIV/60162694:G44__/20:00555520
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4zL-lz8JpP" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4zL-lz8JpP</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules25030532" target="_blank" >10.3390/molecules25030532</a>
Alternative languages
Result language
angličtina
Original language name
Substituted piperazines as novel potential radioprotective agents
Original language description
The increasing risk of radiation exposure underlines the need for novel radioprotective agents. Hence, a series of novel 1-(2-hydroxyethyl)piperazine derivatives were designed and synthesized. Some of the compounds protected human cells against radiation-induced apoptosis and exhibited low cytotoxicity. Compared to the previous series of piperazine derivatives, compound 8 exhibited a radioprotective effect on cell survival in vitro and low toxicity in vivo. It also enhanced the survival of mice 30 days after whole-body irradiation (although this increase was not statistically significant). Taken together, our in vitro and in vivo data indicate that some of our compounds are valuable for further research as potential radioprotectors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GA17-13541S" target="_blank" >GA17-13541S: Development of novel radioprotective agents based on small molecule inhibitors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
—
Volume of the periodical
25
Issue of the periodical within the volume
3
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
532
UT code for WoS article
000515384800102
EID of the result in the Scopus database
2-s2.0-85078687971