Serum levels of selected cytokines and soluble adhesion molecules in acute myeloid leukemia: Soluble receptor for interleukin-2 predicts overall survival
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F20%3A10412222" target="_blank" >RIV/00179906:_____/20:10412222 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/20:00555692
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9PlCgPKa1O" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9PlCgPKa1O</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cyto.2020.155005" target="_blank" >10.1016/j.cyto.2020.155005</a>
Alternative languages
Result language
angličtina
Original language name
Serum levels of selected cytokines and soluble adhesion molecules in acute myeloid leukemia: Soluble receptor for interleukin-2 predicts overall survival
Original language description
Background: Acute myeloid leukemia (AML) cells are highly resistant to chemotherapeutic drugs. Cytokines and adhesion molecules may contribute to this resistance and affect treatment outcome. The aim of this study was to evaluate the independence and additional prognostic information of baseline serum levels of selected cytokines and soluble adhesion molecules, included in analyses with standard prognostic indicators. Methods: We used biochip array technology to measure levels of selected cytokines and soluble adhesion molecules in serum samples of 80 newly diagnosed AML patients. The markers of tumour microenvironment were analysed against high risk karyotype, hyperleucocytosis, higher age, lactic dehydrogenase levels and presence of FLT3-ITD and NPM-1 mutation. Results: All evaluated analytes were independent of standard prognostic indicators. Fifteen were associated with overall and eight with progression-free survival in univariate analysis. After correction for multiple testing, we identified soluble interleukin-2 receptor-alpha as an independent indicator of overall survival. Further, the soluble type I INF-alpha receptor was close to statistical significance for both overall and progression-free survival. Conclusions: Baseline levels of soluble interleukin-2 receptor-alpha predict overall survival in newly diagnosed AML. The TNF-alpha type 1 soluble receptor is a candidate prognostic marker in AML and is worth of further investigation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cytokine
ISSN
1043-4666
e-ISSN
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Volume of the periodical
128
Issue of the periodical within the volume
April
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
155005
UT code for WoS article
000518491500010
EID of the result in the Scopus database
2-s2.0-85078461239