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Expression of cholinesterases and their anchoring proteins in rat heart

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F20%3A10418529" target="_blank" >RIV/00179906:_____/20:10418529 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-iu61gQVY1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-iu61gQVY1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1139/cjpp-2019-0565" target="_blank" >10.1139/cjpp-2019-0565</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Expression of cholinesterases and their anchoring proteins in rat heart

  • Original language description

    Acetylcholine (ACh)-mediated vagal transmission as well as nonneuronal ACh release are considered cardioprotective in pathological situations with increased sympathetic drive such as ischemia-reperfusion and cardiac remodeling. ACh action is terminated by hydrolysis by the cholinesterases (ChEs), acetylcholinesterase, and butyrylcholinesterase. Both ChEs exist in multiple molecular variants either soluble or anchored by specific anchoring proteins like collagen Q(ColQ) anchoring protein and proline-rich membrane anchoring protein (PRiMA). Here we assessed the expression of specific ChE molecular forms in different heart compartments using RT-qPCR. We show that both ChEs are expressed in all heart compartments but display different expression patterns. The acetylcholinesterase-T variant together with PRiMA and ColQ is predominantly expressed in rat atria. Butylcholinesterase is found in all heart compartments and is accompanied by both PRiMA and ColQ anchors. Its expression in the ventricular system suggests involvement in the nonneuronal cholinergic system. Additionally, two PRiMA variants are detected throughout the rat heart.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Canadian Journal of Physiology and Pharmacology

  • ISSN

    0008-4212

  • e-ISSN

  • Volume of the periodical

    98

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    CA - CANADA

  • Number of pages

    4

  • Pages from-to

    473-476

  • UT code for WoS article

    000548660400007

  • EID of the result in the Scopus database

    2-s2.0-85087878534