Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10126804" target="_blank" >RIV/00216208:11140/12:10126804 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/12:11484 RIV/46747885:24610/12:#0000011
Result on the web
<a href="http://dx.doi.org/10.1111/j.1471-4159.2012.07856.x" target="_blank" >http://dx.doi.org/10.1111/j.1471-4159.2012.07856.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1471-4159.2012.07856.x" target="_blank" >10.1111/j.1471-4159.2012.07856.x</a>

Result language
angličtina
Original language name
Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase
Original language description
J. Neurochem. (2012) 122, 10651080. Abstract Acetylcholinesterase (AChE) rapidly hydrolyzes acetylcholine. At the neuromuscular junction, AChE is mainly anchored in the extracellular matrix by the collagen Q, whereas in the brain, AChE is tethered by theproline-rich membrane anchor (PRiMA). The AChE-deficient mice, in which AChE has been deleted from all tissues, have severe handicaps. Surprisingly, PRiMA KO mice in which AChE is mostly eliminated from the brain show very few deficits. We now report that most of the changes observed in the brain of AChE-deficient mice, and in particular the high levels of ambient extracellular acetylcholine and the massive decrease of muscarinic receptors, are also observed in the brain of PRiMA KO. However, the two groups of mutants differ in their responses to AChE inhibitors. Since PRiMA-KO mice and AChE-deficient mice have similar low AChE concentrations in the brain but differ in the AChE content of the peripheral nervous system, these results su
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/GA309%2F09%2F0406" target="_blank" >GA309/09/0406: Muscarinic receptor regulation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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