A comprehensive study on the degradation process of medical-grade polydioxanone at low pH
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10483900" target="_blank" >RIV/00179906:_____/24:10483900 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/24:50021665 RIV/00216208:11150/24:10483900 RIV/00216275:25310/24:39922013
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=473L7HOLih" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=473L7HOLih</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.polymertesting.2024.108536" target="_blank" >10.1016/j.polymertesting.2024.108536</a>
Alternative languages
Result language
angličtina
Original language name
A comprehensive study on the degradation process of medical-grade polydioxanone at low pH
Original language description
Polydioxanone (PPDX) has gained significant attention as a biocompatible and absorbable polymer used various medical applications, such as sutures and tissue scaffolds. This research presents a thorough investigation into the degradation mechanisms of PPDX under low pH conditions, simulating physiological environments, e.g., esophagus and stomach. It mainly focuses on the dependence of the PPDX degradation rate on various ambient pH values (7.4 and below), which is a substantial knowledge for successful gastrointestinal treatment. The PPDX suture samples were degraded for up to 6 weeks and analyzed using size exclusion chromatography, differential scanning calorimetry, Raman spectroscopy, scanning electron microscopy, X-ray microtomography, and mechanical property measurements. The results show that the PPDX degradation is significantly accelerated at pH below 1.67. Correlations of the molecular weight, crystallinity, glass transition temperature, Young's modulus, shear modulus, tensile strength, and the 1733 cm-- 1 Raman peak shoulder area (RPSA1733) indicate that the degradation mechanism does not change with increasing acidity. Measurements of tensile strength, shear modulus, and RPSA1733 were found to be the most suitable parameters for characterizing the PPDX filament's macroscopic integrity. Raman spectroscopy is of particular interest in this regard due to its rapidity and practically no requirements on the sample preparation.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymer Testing
ISSN
0142-9418
e-ISSN
1873-2348
Volume of the periodical
138
Issue of the periodical within the volume
SEP
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
108536
UT code for WoS article
001293426400001
EID of the result in the Scopus database
2-s2.0-85200816288