History of cervical excisional treatment is associated with changes in the cervical microbiota in women with preterm prelabor rupture of membranes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10488181" target="_blank" >RIV/00179906:_____/24:10488181 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/24:10488181

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gOQ9rXbKzU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gOQ9rXbKzU</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/14767058.2024.2425761" target="_blank" >10.1080/14767058.2024.2425761</a>

Result language

angličtina

Original language name

History of cervical excisional treatment is associated with changes in the cervical microbiota in women with preterm prelabor rupture of membranes

Original language description

Background: This study aimed to determine the differences in the cervical load and prevalence of Lactobacillus crispatus DNA, Lactobacillus iners DNA, Gardnerella vaginalis DNA, Sneathia sanguinegens DNA, and Ureaplasma species DNA between pregnant women with preterm prelabor rupture of membranes (PPROM) with and without a history of cervical excisional treatment. We also assessed the changes in the cervical load and prevalence of L. crispatus DNA, L. iners DNA, G. vaginalis DNA, S. sanguinegens DNA, and U. spp DNA. according to the cone length. Methods: This retrospective study included 132 women with singleton pregnancies complicated by PPROM. For all women, information about the cervical loads of bacterial DNA corresponding to L. crispatus, L. iners, G. vaginalis, S. sanguinegens, and U. spp., which was assessed using PCR, was available. Results: Women with a history of cervical excisional treatment had a higher cervical load of L. iners DNA (4.4 x 10(6) copies DNA/mL vs. 3.5 x 10(5) copies DNA/mL, p = .04) and a higher load and prevalence of U. spp. DNA (1.1 x 10(5) copies DNA/mL vs. 9.6 x 10(4) copies DNA/mL, p = .03; 2.7% vs. 0.5%, p = .04) than those without a history of cervical excisional treatment. In the subset of women with a history of cervical excisional treatment, those with a cone length 18 mm and more had a lower relative abundance of L. crispatus DNA (6% vs. 89%, p = .02), a higher load and relative abundance of L. iners DNA (1.1 x 10(7) copies DNA/mL vs. 8.2 x 10(5) copies DNA/mL, p = .04; 91% vs. 35%, p = .04), and higher loads of G. vaginalis DNA (7.6 x 10(4) copies DNA/mL vs. 3.2 x 10(2) copies DNA/mL, p = .02) than those with cone length &lt; 18 mm. Conclusions: A history of cervical excisional treatment was associated with alterations in the cervical microbiota composition in pregnant women with PPROM.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The Journal of Maternal-Fetal &amp; Neonatal Medicine

ISSN

1476-7058

e-ISSN

1476-4954

Volume of the periodical

37

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

2425761

UT code for WoS article

001355207800001

EID of the result in the Scopus database

2-s2.0-85209372331