Real-World Experience With Venetoclax-Based Therapy in Acute Myeloid Leukemia: Insights From the Czech Republic
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10500374" target="_blank" >RIV/00179906:_____/25:10500374 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/25:A2603DNS RIV/00216208:11110/25:10500374 RIV/00216208:11120/25:43928687 RIV/00216208:11140/25:10500374 and 6 more
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p8IN-fFb~C" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p8IN-fFb~C</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clml.2025.06.021" target="_blank" >10.1016/j.clml.2025.06.021</a>
Alternative languages
Result language
angličtina
Original language name
Real-World Experience With Venetoclax-Based Therapy in Acute Myeloid Leukemia: Insights From the Czech Republic
Original language description
Background: Venetoclax (VEN) combined with azacitidine (AZA) has become the standard treatment for patients (pts) with newly diagnosed (ND) acute myeloid leukemia (AML) who are unfit for intensive chemotherapy. This study reports on a real-world cohort of 163 patients with ND AML treated with VEN/AZA across 7 hospitals in the Czech Republic. Patients and Methods: The median age at diagnoses was 72 (39-98) years. Standard VEN/AZA (7 + 28; ie, AZA 75mg/m<sup>2</sup> for 7 days + VEN for 28 days) was used in 89% of patients (145/163), with 73% (119/163) receiving a reduced dose of venetoclax (100 mg or 200 mg) due to concomitant azole antifungal prophylaxis. Treatment was considered palliative or nonintensive (including potential allogeneic transplant candidates) based on the clinician's decision. Results: Among 150 evaluable patients, 71% (107/150) achieved composite complete remission (CCR = CR + CRi), with 28% (32/115) achieving MRD negativity. Median overall survival (OS) was 5 months for the palliative cohort and 21 months for the nonintensive cohort. Day 30 and day 60 mortality rate were 7% and 13%, respectively. Allogeneic transplantation (HSCT) was performed in 15% (25/163) of pts, with the median OS not reached in this group. Mutations in NPM1, and IDH1/2 were associated with improved survival, while FLT3, ASXL1, TP53, deletion/monosomy 7, and complex karyotype were linked to poorer outcomes. Conclusion: Data suggest that TP53 patients benefit from treatment if they achieve CR within the first 2 cycles. Discontinuing VEN/AZA in low-risk MRD-negative patients does not appear to worsen overall survival, though long-term outcomes remain to be seen.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Lymphoma, Myeloma & Leukemia
ISSN
2152-2650
e-ISSN
2152-2669
Volume of the periodical
25
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
"e1022"-"e1032"
UT code for WoS article
001628851500010
EID of the result in the Scopus database
2-s2.0-105011984623