Postremission cytopenia management in patients with acute myeloid leukemia treated with venetoclax and azacitidine in VIALE-A
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F22%3A00076298" target="_blank" >RIV/65269705:_____/22:00076298 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/22:00128097
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.26692" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.26692</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.26692" target="_blank" >10.1002/ajh.26692</a>
Alternative languages
Result language
angličtina
Original language name
Postremission cytopenia management in patients with acute myeloid leukemia treated with venetoclax and azacitidine in VIALE-A
Original language description
The phase 3 VIALE-A study (NCT02993523) of venetoclax (Ven) + azacitidine (Aza) demonstrated significantly improved median overall survival (OS; 14.7 months) compared with placebo (Pbo) + Aza in patients with newly diagnosed acute myeloid leukemia (AML) who were aged GREATER-THAN OR EQUAL TO75 years or ineligible for intensive chemotherapy.1 The study protocol recommended dosing schedule modification following remission to mitigate hematologic adverse events (AEs; Figure 1A); these occurred in 83% of patients in the Ven + Aza arm. This post hoc analysis of VIALE-A evaluated the frequency and management of postremission cytopenia events, Ven exposure-response relationship with postremission cytopenias, and outcomes when dosing schedule modifications were required for grade 4 cytopenias.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Hematology
ISSN
0361-8609
e-ISSN
1096-8652
Volume of the periodical
97
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
"E416"-"E419"
UT code for WoS article
000854058000001
EID of the result in the Scopus database
2-s2.0-85137974335