Urinary Calcium and Phosphorus Excretion in Vitamin D-Sufficient Preterm Infants: Establishing Age-Specific Normative Data
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10500470" target="_blank" >RIV/00179906:_____/25:10500470 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/25:00384616 RIV/00216208:11150/25:10500470
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hPP.9-fsyW" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hPP.9-fsyW</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apa.70253" target="_blank" >10.1111/apa.70253</a>
Alternative languages
Result language
angličtina
Original language name
Urinary Calcium and Phosphorus Excretion in Vitamin D-Sufficient Preterm Infants: Establishing Age-Specific Normative Data
Original language description
Aim: This study evaluated urinary calcium (Ca) and phosphorus (P) excretion in very low birth weight infants ( < 1500 g, VLBW) without severe morbidity, treated with methylxanthines. Methods: Eighty-one VLBW infants were analysed. Urinary Ca and P and their creatinine ratios were measured biweekly until day 56. Serum parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH)D], total Ca, P and alkaline phosphatase (ALP) were assessed. Bone densitometry was performed before discharge. Results: In 254 urine samples, urinary Ca and P excretion differed significantly from their creatinine ratios. Vitamin D status influenced urinary mineral excretion, likely via PTH regulation, but did not affect serum Ca, P, or ALP. Normative data were established only for infants with serum 25-(OH)D > 50 nmol/L. Due to age-related variability, a single reference range was not possible. Conclusions: We provide age-specific normative data for urinary Ca and P excretion in healthy VLBW infants with sufficient vitamin D. Urinary mineral excretion varies significantly with postnatal age, emphasising the need for individualised monitoring to prevent metabolic bone disease of prematurity. Vitamin D status is crucial for calcium-phosphorus homeostasis, with sufficient levels linked to increased Ca excretion and relative P depletion from the 2 month of life.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Paediatrica
ISSN
0803-5253
e-ISSN
1651-2227
Volume of the periodical
114
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
3267-3278
UT code for WoS article
001543585400001
EID of the result in the Scopus database
2-s2.0-105012275633