Quality evaluation of synthetic CT using a gamma analysis for prostate cancer MR-only radiotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10502990" target="_blank" >RIV/00179906:_____/25:10502990 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/25:00001556
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ms6.2j1ZoG" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ms6.2j1ZoG</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5603/rpor.105857" target="_blank" >10.5603/rpor.105857</a>
Alternative languages
Result language
angličtina
Original language name
Quality evaluation of synthetic CT using a gamma analysis for prostate cancer MR-only radiotherapy
Original language description
Background: This study evaluates the quality of synthetic computed tomography (sCT) images for MR-only radiotherapy in prostate cancer using gamma analysis. A software tool, MRGamma, was developed to address challenges like the absence of electron density maps and registration uncertainties between magnetic resonance imaging (MRI) and planning CT (pCT). Materials and methods: Aplication developed in MATLAB assesses Hounsfield units (HU) discrepancies between CT and sCT images via 2D and 3D gamma analysis (GA). GA computes a gamma index (gamma) for each voxel based on HU differences and distance to agreement (DTA). The study analyzed prostate cancer patients using the MRCAT algorithm to generate sCT images. Preprocessing included registration, resampling, and cropping to standardize image dimensions. GA was performed with thresholds of 100 HU and 70 HU for HU differences and 3 mm for DTA to evaluate image quality. Results: Aplication demonstrated high agreement between sCT and CT images. For 3D GA (100 HU, 3 mm), 95.5 +/- 1.8% of voxels passed the threshold, with slightly lower rates for 70 HU. Discrepancies were most pronounced at tissue interfaces and air cavities, where HU variations were more significant. Mean gamma values for 3D GA were 0.19 +/- 0.04 (milder parameters) and 0.23 +/- 0.05 (stricter parameters), showing consistent trends in 2D GA. Maximum gamma values confirmed good overall agreement. Conclusions: Aplication effectively evaluates sCT quality, supporting the feasibility of MR-only radiotherapy. By providing detailed HU comparisons, the tool enhances MR-based treatment planning, reducing costs and ionizing radiation exposure. Its implementation may improve workflow efficiency and patient safety in clinical practice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Reports of Practical Oncology and Radiotherapy
ISSN
1507-1367
e-ISSN
2083-4640
Volume of the periodical
30
Issue of the periodical within the volume
2
Country of publishing house
PL - POLAND
Number of pages
8
Pages from-to
298-305
UT code for WoS article
001563416300001
EID of the result in the Scopus database
2-s2.0-105021519015