Circadian rhythm in mycotoxin-induced immunotoxicity: an emerging regulatory axis?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10505408" target="_blank" >RIV/00179906:_____/25:10505408 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18450/25:50022799 RIV/62690094:18470/25:50022799 RIV/61989100:27360/25:10259719
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=OTCj.QCRWH" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=OTCj.QCRWH</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphar.2025.1700863" target="_blank" >10.3389/fphar.2025.1700863</a>
Alternative languages
Result language
angličtina
Original language name
Circadian rhythm in mycotoxin-induced immunotoxicity: an emerging regulatory axis?
Original language description
Mycotoxins, toxic secondary metabolites produced by fungi, pose a substantial worldwide health risk due to their widespread contamination of food commodities. Their toxicological effects include organ dysfunction, oxidative stress, and suppression of immune function. Emerging data indicate that circadian rhythm disruption is a critical but underrecognized mechanism contributing to mycotoxin-induced toxicity. This review summarizes current evidence showing that mycotoxins directly interfere with molecular circadian rhythm regulators. Specifically, deoxynivalenol markedly downregulates the expression of BMAL1, CLOCK, and CRY1/2 in hepatic cells. Similarly, zearalenone perturbs the temporal expression of BMAL1, PER2, and NR1D1 in testicular tissue, impairing testosterone biosynthesis. Furthermore, circadian rhythm disruption triggered by mycotoxins may initiate downstream pathological responses, including enhanced ROS generation and immune dysfunction through BMAL1-dependent regulation of PD-L1 expression. Importantly, a reciprocal feedback loop appears to exist wherein oxidative stress intensifies circadian rhythm disruption, which in turn promotes ROS accumulation and further immune impairment. These insights establish circadian rhythm disruption as a central mediator of mycotoxin-related toxicity and highlight BMAL1 as a potential therapeutic target. Nonetheless, experimental validation remains limited, and further mechanistic studies are required. We propose that circadian rhythm disruption may serve as an integrative node within the mycotoxin toxicity pathway, linking oxidative imbalance to immunosuppressive outcomes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/EH22_008%2F0004631" target="_blank" >EH22_008/0004631: Materials and technologies for sustainable development</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Pharmacology
ISSN
1663-9812
e-ISSN
1663-9812
Volume of the periodical
16
Issue of the periodical within the volume
October
Country of publishing house
CH - SWITZERLAND
Number of pages
6
Pages from-to
1700863
UT code for WoS article
001608093000001
EID of the result in the Scopus database
2-s2.0-105021081190