Evaluation of novel surfactants for the decontamination of chemical warfare agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10506739" target="_blank" >RIV/00179906:_____/25:10506739 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/26:00566019
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4OKhJN-rmX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4OKhJN-rmX</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15376516.2025.2554912" target="_blank" >10.1080/15376516.2025.2554912</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of novel surfactants for the decontamination of chemical warfare agents
Original language description
The decontamination of chemical warfare agents or compounds involved in chemical industry incidents poses a significant challenge to environmental protection and human health. These compounds are highly toxic and could be relatively resistant to conventional decontamination methods. In recent years, surfactants have emerged as a promising option, as they can enhance the solubility of organophosphorus compounds in aqueous solutions while promoting their degradation or adsorption onto surfaces. In this study, 35 compounds (surfactants based on quartenary ammonium salts) were tested using the model pesticide fenitrothion, with the compounds from the 43 C series (quaternary ammonium salts with two hydroxyl functional groups) showing the highest decontamination potential. The 43 C series compounds were further tested in vitro for the degradation of nerve agents sarin, soman, and VX, as well as the blistering agent sulfur mustard. The compounds labeled 43C14 and 43C16 (benzoxonia with the 14- and 16-carbon chains) exhibited the best potential. Due to the possible use in protective applications for military personnel, an in vivo acute skin irritation test on 43C14 and 43C16 was also conducted in rats. No skin pathology was observed after a 4-h application and during the subsequent 72-h observation period, suggesting its potential for practical use.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/NW25-08-00088" target="_blank" >NW25-08-00088: Antimicrobial boost of 3D-Printable Calcium Phosphate Cements Using Quaternary Ammonium Salts: Towards Biocompatible Self-Disinfecting Getters</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology Mechanisms and Methods
ISSN
1537-6516
e-ISSN
1537-6524
Volume of the periodical
35
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
1588-1601
UT code for WoS article
001566068300001
EID of the result in the Scopus database
2-s2.0-105015586813