Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F21%3A00557213" target="_blank" >RIV/60162694:G44__/21:00557213 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/21:10432514
Result on the web
<a href="https://www.mdpi.com/2305-6304/9/9/222/htm" target="_blank" >https://www.mdpi.com/2305-6304/9/9/222/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/toxics9090222" target="_blank" >10.3390/toxics9090222</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts
Original language description
Benzoxonium chloride belongs to the group of quaternary ammonium salts, which have been widely used for decades as disinfectants because of their high efficacy, low toxicity, and thermal stability. In this study, we have prepared the C10-C18 set of benzoxonium-like salts to evaluate the effect of their chemical and biological decontamination capabilities. In particular, biocidal activity against a panel of bacterial strains including Staphylococcus aureus in biofilm form was screened. In addition, the most promising compounds were successfully tested against Francisella tularensis as a representative of potential biological warfare agents. From a point of view of chemical warfare protection, the efficiency of BOC-like compounds to degrade the organophosphate simulant feni-trothion was examined. Notwithstanding that no single compound with universal effectiveness was identified, a mixture of only two compounds from this group would be able to satisfactorily cover the proposed decontamination spectrum. In addition, the compounds were evaluated for their cytotoxic-ity as a basic safety parameter for potential use in practice. In summary, the dual effect on chemical and biological agents of benzoxonium-like salts offer attractive potential as active components of decontamination mixtures in the case of a terrorist threat or chemical or biological accidents.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxics
ISSN
2305-6304
e-ISSN
2305-6304
Volume of the periodical
9
Issue of the periodical within the volume
9
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
222
UT code for WoS article
000701176500001
EID of the result in the Scopus database
2-s2.0-85115327317