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Impact of inflammatory infiltration and viral genome presence in myocardium on the changes of echocardiogrraphic parameters

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F13%3A%230000266" target="_blank" >RIV/00209775:_____/13:#0000266 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.crvasa.2013.02.003" target="_blank" >http://dx.doi.org/10.1016/j.crvasa.2013.02.003</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.crvasa.2013.02.003" target="_blank" >10.1016/j.crvasa.2013.02.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Impact of inflammatory infiltration and viral genome presence in myocardium on the changes of echocardiogrraphic parameters

  • Original language description

    Seventy patients with a recent occurrence of DCM with left ventricle ejection fraction (LVEF) <40% and with the history of symptoms less than 12 months were enrolled to observation. In EMB samples the average number of T-lymphocytes (CD3+ cells) and mononuclear leucocytes (LCA+ cells) in mm2 was determined. The presence of inflammation was evaluated as positive in case of the findings of >7 CD3+ cells and/or >14 LCA+ cells in mm2. The detection of pathological agents in myocardium was performed by quantitative PCR. According to immunohistological (IH) assessment findings were positive (IH+) in 35 patients (i.e. 50%); thus the inflammatory infiltration was present in myocardium. In remaining patients the findings were negative (IH-). At 6 months follow-up, in the group of IH+ patients the LVEF improved from 25+-9% to 39+-11% and NYHA class declined from 2.8+-0.5 to 1.7+-0.6 (both p<0.001). In IH- group change in LVEF (from 23+-8% to 27+-10%) in contrast to the change of NYHA class (from

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cor et Vasa

  • ISSN

    0010-8650

  • e-ISSN

  • Volume of the periodical

    55

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    8

  • Pages from-to

    "E333"-"E340"

  • UT code for WoS article

  • EID of the result in the Scopus database