Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065537" target="_blank" >RIV/00159816:_____/16:00065537 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00090789

Result on the web

<a href="http://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=1371&type=fin&ver=3" target="_blank" >http://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=1371&type=fin&ver=3</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Original language description

Aims: To compare the differences between patients with inflammatory cardiomyopathy (ICM) with and without improvement in left ventricular (LV) systolic function and to identify the relevant predictors of LV improvement. Patients and Methods: The study included 63 patients with biopsy-proven ICM and heart failure symptoms of at least NYHA II, symptom duration LESS-THAN OR EQUAL TO 6 months, LV ejection fraction (LVEF) LESS-THAN OR EQUAL TO 40% assessed by echocardiography and presence of >14 mononuclear leukocytes (LCA+ cells)/mm2 in biopsy samples. Patients were evaluated at baseline and after 6 months. Results: In the group with LVEF improvement of GREATER-THAN OR EQUAL TO 10% (I+ group, n = 41), LVEF increased from 24 +- 7% to 47 +- 8% (P < 0.001). In 22 patients (group I-), there was no or minimal LVEF increase (< 10%). In the I+ group, there were more LCA+ cells/mm2 at baseline (25.1 +- 16.5 vs. 18.5 +- 4.4 cells/mm2; P = 0.032) and a more significant decrease in LCA+ cells in the follow-up (reduction of 13.6 +- 14.3 cells/mm2 vs. 5.0 +- 7.7 cells/mm2 in the I- group; P = 0.009). The univariate logistic regression showed a possible association of number of LCA+ cells, LV end-diastolic diameter and N-terminal fragment of pro-brain natriuretic peptide (NTproBNP) value with LVEF improvement. In the multivariate analysis, only NTproBNP at diagnosis was confirmed as an independent predictor of LVEF improvement (OR=1.2; 1.003 to 1.394; P = 0.046). Conclusion: The LV systolic function improvement was observed in 65% of the patients. In these patients, the number of inflammatory cells at baseline was higher and decreased more but the higher baseline NTproBNP value was the only independent predictor of LVEF improvement.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/NT14087" target="_blank" >NT14087: Complex biopsy-based diagnostics of inflammatory and viral myocardial disorders</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

160

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

524-532

UT code for WoS article

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EID of the result in the Scopus database

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