Correlations of the changes in bioptic findings with echocardiographic, clinical and laboratory parameters in patients with inflammatory cardiomyopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00062941" target="_blank" >RIV/00159816:_____/16:00062941 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00089216 RIV/00209775:_____/16:N0000012

Result on the web

<a href="http://dx.doi.org/10.1007/s00380-014-0618-0" target="_blank" >http://dx.doi.org/10.1007/s00380-014-0618-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00380-014-0618-0" target="_blank" >10.1007/s00380-014-0618-0</a>

Result language

angličtina

Original language name

Correlations of the changes in bioptic findings with echocardiographic, clinical and laboratory parameters in patients with inflammatory cardiomyopathy

Original language description

Patients with myocarditis and left ventricular (LV) dysfunction may improve after standard heart failure therapy. This improvement seems to be related to retreat of myocardial inflammation. The aim of the present study was to assess changes in clinical, echocardiographic and some laboratory parameters and to correlate them with changes in the number of inflammatory infiltrating cells in endomyocardial biopsy (EMB) samples during the 6-month follow-up, and to define predictors of LV function improvement among baseline parameters. Forty patients with biopsy-proven myocarditis and impaired LV function (LV ejection fraction-LVEF <40 %) with heart failure symptoms LESS-THAN OR EQUAL TO6 months were evaluated. Myocarditis was defined as the presence of >14 mononuclear leukocytes/mm2 and/or >7 T-lymphocytes/mm2 in the baseline EMB. The EMB, echocardiography and clinical evaluation were repeated after 6 months of standard heart failure therapy. LVEF improved on average from 25 +- 9 to 42 +- 12 % (p < 0.001); LV end-systolic volume and LV end-diastolic volume (LVEDV) decreased from 158 +- 61 to 111 +- 58 ml and from 211 +- 69 to 178 +- 63 ml (both p < 0.001). NYHA class decreased from 2.6 +- 0.5 to 1.6 +- 0.6 (p < 0.001) and NTproBNP from 2892 +- 3227 to 851 +- 1835 µg/ml (p < 0.001). A decrease in the number of infiltrating leukocytes (CD45+/LCA+) from 23 +- 15 to 13 +- 8 cells/mm2 and in the number of infiltrating T lymphocytes (CD3+) from 7 +- 5 to 4 +- 3 cells/mm2 (both p < 0.001) was observed.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Heart and Vessels

ISSN

0910-8327

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

416-426

UT code for WoS article

000371803600017

EID of the result in the Scopus database

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