Viral genome changes and the impact of viral genome persistence in myocardium of patients with inflammatory cardiomyopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069361" target="_blank" >RIV/00159816:_____/18:00069361 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00104916

Result on the web

<a href="http://dx.doi.org/10.5114/aoms.2018.79002" target="_blank" >http://dx.doi.org/10.5114/aoms.2018.79002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/aoms.2018.79002" target="_blank" >10.5114/aoms.2018.79002</a>

Result language

angličtina

Original language name

Viral genome changes and the impact of viral genome persistence in myocardium of patients with inflammatory cardiomyopathy

Original language description

Introduction: Viral infections are considered the most frequent cause of myocarditis and dilated cardiomyopathy (DCM). Material and methods: We investigated the changes in viral presence and the impact of viral genome persistence in the myocardium on echocardio-graphic parameters, functional status and some laboratory parameters in a 6-month follow-up. Fifty-four patients with recent onset DCM, left ventricular ejection fraction &lt; 40% and biopsy-proven myocarditis (&gt; 14 mononuclear leukocytes/mm(2) and/or &gt; 7 T-lymphocytes/mm(2)) were enrolled. Polymerase chain reaction (PCR) was performed to detect pathogens in the myocardium. Patients were divided according to the administered therapy: standard heart failure medication (46 patients) and immunosuppressive therapy (8 patients). Results: In the standard heart failure medication group viral clearance was observed in 13 patients and viral persistence in 24 patients in the follow-up period. Comparing both groups, there was no statistically significant difference - LVEF improvement of 12.0 +/- 11.4% vs. 18.3 +/- 12.6%, decrease in NYHA class of 0.7 +/- 0.7 vs. 1.0 +/- 0.7, decline in NT-proBNP of 1335 +/- 1933 ng/I vs. 1942 +/- 3242 ng/I and decrease in infiltrating leukocytes of 11.1 +/- 15.8 vs. 6.7 +/- 23.0 cells/mm(2) and T-lymphocytes of 5.8 +/- 15.1 vs. 1.8 +/- 10.9 cells/mm(2) (all p = NS). A decrease in PCR positive patients from 37 to 29 was observed. The number of PVB19 positive PCR findings decreased from 5 to 4 in patients with immunosuppressive therapy. Conclusions: A decrease in the number of positive PCR findings in control endomyocardial biopsy was observed. Viral genome persistence was not associated with worse outcome in short-term follow-up.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30218 - General and internal medicine

Project

<a href="/en/project/NT14087" target="_blank" >NT14087: Complex biopsy-based diagnostics of inflammatory and viral myocardial disorders</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Medical Science

ISSN

1734-1922

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

6

Country of publishing house

PL - POLAND

Number of pages

9

Pages from-to

1245-1253

UT code for WoS article

000448045000005

EID of the result in the Scopus database

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