Effects of oxidation agents and metal ions on binding of p53 to supercoiled DNA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F00%3A00000095" target="_blank" >RIV/00209805:_____/00:00000095 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/00:17010206

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effects of oxidation agents and metal ions on binding of p53 to supercoiled DNA

Original language description

Wild type human full length tumor suppressor p53 protein binds preferentially to supercoiled DNA in vitro both in the presence and absence of the p53 consensus sequence. The amount of p53-scDNA complexes were decreased by physiological concentrations ofunchelated zinc ions while nickel and cobalt ions inhibited binding of p53 to scDNA and to p53CON in linear DNA fragments less efficiently than zinc. Oxidation of the p53 protein with diamide resulted in its decrease binding to both supercoiled and linear DNAs due to the probable change in the p53 conformation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biomolecular Structure and Dynamics

ISSN

0739-1102

e-ISSN

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Volume of the periodical

2000

Issue of the periodical within the volume

S1

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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