Cyclin-dependent kinase inhibitors induce a transcriptionally active form of p53 protein associated with nucleolar segregation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F00%3A00000096" target="_blank" >RIV/00209805:_____/00:00000096 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Cyclin-dependent kinase inhibitors induce a transcriptionally active form of p53 protein associated with nucleolar segregation

Original language description

The wild-type p53 protein is a critical participant in cellular responses to various cytotoxic stresses and its induction can result in either cell cycle arrest or in apoptotic cell death. Cyclin-dependent kinases (CDKs) play a key role in regulation ofcellular proliferation and apoptosis by phosphorylating many regulatory proteins including tumour suppressor p53. Recently, a new purine derivative olomoucine and roscovitine were described. They act as a potent inhibitors of the CDK1 and related kinases(CDK2, CDK5, erk1 and erk2). We have detected significant induction of wild-type but not mutant p53 protein after treatment the tumour cell lines with previously mentioned inhibitors.The induced p53 protein remains transcriptionally active.

Czech name

—

Czech description

—

Type

D - Article in proceedings

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

10th international p53 workshop

ISBN

—

ISSN

—

e-ISSN

—

Number of pages

1

Pages from-to

—

Publisher name

neuv.

Place of publication

Monterey

Event location

—

Event date

—

Type of event by nationality

—

UT code for WoS article

—