Segregation of nucleolar compo-nents coincides with immunoreactivity for active caspase 3 in cisplatin - treated HeLa cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F00%3A00000097" target="_blank" >RIV/00209805:_____/00:00000097 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Segregation of nucleolar compo-nents coincides with immunoreactivity for active caspase 3 in cisplatin - treated HeLa cells

Original language description

We studied morphological changes of the nucleoli in HeLa cells treated with cisplatin and compared them with induction of markers of programmed cell death and TUNEL staining. Our results show predominantly compact, centrally localized nucleoli in intactcontrol HeLa cells. In conclusion, remarkable segregation of nucleolar argyrophilic proteins, nucleolar RNA and a simultaneous activation of the cascade of caspases markedly preceded the TUNEL positivity in cisplatin-treated HeLa cells thereby substantiating the hypothesis that the nucleolus is a preferred target for caspase-3-dependent proteolysis in cisplatin-treated HeLa cells.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

4th International Multi-disciplinary Congress - Global Challenge of Cervical Cancer Prevention - EUROGIN 2000

ISBN

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ISSN

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e-ISSN

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Number of pages

1

Pages from-to

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Publisher name

neuv.

Place of publication

Paris

Event location

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Event date

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Type of event by nationality

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UT code for WoS article

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