Posttranslational modification of mutant p53 protein in different tumor cell lines after UV light damage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F00%3A00000101" target="_blank" >RIV/00209805:_____/00:00000101 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Posttranslational modification of mutant p53 protein in different tumor cell lines after UV light damage

Original language description

Tumor suppressor protein p53 represents one of the most important factors regulating cell proliferation, differentiation and programmed cell death in normal cells. Transformation of latent form of p53 to the active form by means of posttranslational modimodification includes mainly phosphorylation and acetylation of specific sites. One of the modifications at the casein kinase II (CK II) phosphorylation site in the C-terminal domain of p53 activates the latent specific DNA-binding function of p53 protein in vitro. The aim of this study was to characterize the level of phosphorylation of p53 mutant forms in the different tumour cell lines as a response to UV light irradiation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biomolecular Structure and Dynamics

ISSN

0739-1102

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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