DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F10%3A%230000112" target="_blank" >RIV/00209805:_____/10:#0000112 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation
Original language description
?Np63? is an epithelial progenitor cell marker that maintains epidermal stem cell self-renewal capacity. We now report that phosphorylation of the p53 tumour suppressor is positively regulated by ?Np63? in immortalised human keratinocytes. ?Np63? depletion by RNAi reduces steady-state ATM mRNA and protein levels, and attenuates p53 Serine-15 phosphorylation. Conversely, ectopic expression of ?Np63? in p63-null tumour cells stimulates ATM transcription and p53 Serine-15 phosphorylation. We show that ATMis a direct ?Np63? transcriptional target and that the ?Np63? response element localizes to the ATM promoter CCAAT sequence. Germline p63 point mutations are associated with a range of ectodermal developmental disorders, and targeted p63 deletion in theskin causes premature ageing. The ?Np63?-ATM-p53 damage-response pathway may therefore function in epithelial development, carcinogenesis and the ageing processes.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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