Loss of the p53 tumor suppressor aktivity is associated with negative prognosis of mantle cell lymphoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F10%3A%230000275" target="_blank" >RIV/00209805:_____/10:#0000275 - isvavai.cz</a>

Result on the web

<a href="http://www.spandidos-publications.com/ijo/36/3/699" target="_blank" >http://www.spandidos-publications.com/ijo/36/3/699</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ijo_00000545" target="_blank" >10.3892/ijo_00000545</a>

Result language

angličtina

Original language name

Loss of the p53 tumor suppressor aktivity is associated with negative prognosis of mantle cell lymphoma

Original language description

Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progression of the disease. We analyzed the p53 tumor suppressor in tumor tissue of 33 patients with MCL. The p53 status was determined by functional analyses in yeast (FASAY) and by cDNA sequencing. The level of the p53 protein was assessed by immunohistochemistry and immunoblotting. Loss of the p53-specific locus 17p13.3 was detected by FISH. Mutations in the p53 gene were detected in nine samples and they included eight missense mutations and one short deletion causing frame shift and premature stop codon formation in position 169. This mutation was associated with mRNA decay as revealed by sequencing of the p53 gDNA. All eight missense mutations were manifested by accumulation

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of oncology

ISSN

1019-6439

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

3

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

699-706

UT code for WoS article

000274718400020

EID of the result in the Scopus database

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