Loss of the p53 tumor suppressor activity is associated with negative prognosis of mantle cell lymphoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F10%3A%230000967" target="_blank" >RIV/65269705:_____/10:#0000967 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/10:00051341

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Loss of the p53 tumor suppressor activity is associated with negative prognosis of mantle cell lymphoma

Original language description

Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as abberations of the ARF/MDM2/p53 pathway are also necessary for progression of the disease. We analyzed the p53 tumor suppressor in tumor tissue of 33 patients with MCL. The p53 status was determined by functional analyses in yeast (FASAY) and by cDNA sequencing. The level of the p53 protein was assessed by immunoblotting. Loss of the p53-specific locus 17p13.3 was detected by FISH. Mutations in the p53 gene were detected in nine samples and they included eight missense mutations and one short deletion causingframe shift and premature stop codon formation in position 169.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NR9305" target="_blank" >NR9305: Complex analysis of p53 tumor suppressor in non-Hodgkin´s lymphomas</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Oncology

ISSN

1019-6439

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

5

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

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UT code for WoS article

274718400020

EID of the result in the Scopus database

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