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Divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for reptin

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F10%3A%230000597" target="_blank" >RIV/00209805:_____/10:#0000597 - isvavai.cz</a>

  • Alternative codes found

    RIV/00209805:_____/10:#0000680

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0022283610010235" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022283610010235</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jmb.2010.09.035" target="_blank" >10.1016/j.jmb.2010.09.035</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for reptin

  • Original language description

    Anterior gradient-2 (AGR2) functions in a range of biological systems, including goblet cell formation, limb regeneration, inhibition of p53, and metastasis. There are no well-validated binding proteins for AGR2 protein despite the wealth of data implicating an important cellular function in vertebrates. The yeast two-hybrid system was used to isolate the ATP binding protein Reptin as an AGR2-interacting protein. AGR2 formed a stable complex in human cell lysates with Reptin, thus validating Reptin as an AGR2 binding protein in cells. Reptin was also shown to be overproduced in a panel of primary breast cancer biopsy specimens, relative to normal adjacent tissue from the same patient, suggesting a role in cancer growth in vivo. Mutations were made at the two ATP binding motifs in Reptin to evaluate the effects of ATP on Reptin?AGR2 complex stability. Loss-of-ATP binding mutations at the Walker A motif (K83A) or gain-of- ATP binding mutations at the Walker B motif (D299N) resulted in Re

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of molecular biology

  • ISSN

    0022-2836

  • e-ISSN

  • Volume of the periodical

    404

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    21

  • Pages from-to

    418-438

  • UT code for WoS article

    000285372700007

  • EID of the result in the Scopus database