Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000288" target="_blank" >RIV/00209805:_____/12:#0000288 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S002217591200035X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S002217591200035X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jim.2012.01.013" target="_blank" >10.1016/j.jim.2012.01.013</a>

Result language
angličtina
Original language name
Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models
Original language description
The Anterior Gradient genes AGR2 and AGR3 are part of Protein Disulfide Isomerase (PDI) family and harbour core thioredoxin folds (CxxS motifs) that have the potential to regulate protein folding and maturation. Despite the fact that AGR2 and AGR3 genesare contiguous on chromosome 7p21.1-3, AGR3 protein has rarely been identified along with AGR2 protein. Therefore there is little information on how AGR3 protein is expressed in normal and diseased states. A panel of three monoclonal antibodies was generated towards AGR3 protein for identifying novel clinical models that can be used to define whether AGR3 protein could play a positive or negative role in human cancer development. One monoclonal antibody was AGR3-specific and bound a linear epitope thatcould be defined using both pep-scan and phage-peptide library screening. Using this antibody, endogenous AGR3 protein expression was shown to be cytosolic in four human ovarian cancer subtypes; serous, endometrioid, clear cell, and mucin
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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