Extracellular AGR3 regulates breast cancer cells migration via Src signaling

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078250" target="_blank" >RIV/00209805:_____/19:00078250 - isvavai.cz</a>

Result on the web

<a href="https://www.spandidos-publications.com/10.3892/ol.2019.10849" target="_blank" >https://www.spandidos-publications.com/10.3892/ol.2019.10849</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ol.2019.10849" target="_blank" >10.3892/ol.2019.10849</a>

Result language

angličtina

Original language name

Extracellular AGR3 regulates breast cancer cells migration via Src signaling

Original language description

Human anterior gradient proteins AGR2 and AGR3 are overexpressed in a variety of adenocarcinomas and are often secreted in cancer patients&apos; specimens, which suggests a role for AGR proteins in intra and extracellular compartments. Although these proteins exhibit high sequence homology, AGR2 is predominantly described as a pro-oncogene and a potential prognostic biomarker. However, little is known about the function of AGR3. Therefore, the aim of the present study was to investigate the role of AGR3 in breast cancer. The results demonstrated that breast cancer cells secrete AGR3. Furthermore, it was revealed that extracellular AGR3 (eAGR3) regulates tumor cell adhesion and migration. The current study indicated that the pharmacological and genetic perturbation of Src kinase signaling, through treatment with Dasatinib (protein kinase inhibitor) or investigating cells that express a dominant-negative form of Src, significantly abrogated eAGR3-mediated breast cancer cell migration. Therefore, the results indicated that eAGR3 may control tumor cell migration via activation of Src kinases. The results of the present study indicated that eAGR3 may serve as a microenvironmental signaling molecule in tumor-associated processes.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology letters

ISSN

1792-1074

e-ISSN

—

Volume of the periodical

18

Issue of the periodical within the volume

5

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

4449-4456

UT code for WoS article

000456553900004

EID of the result in the Scopus database

2-s2.0-85042941761