Focal Adhesion Kinase functions as an Akt downstream target in migration of colorectal cancer cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F09%3A00335669" target="_blank" >RIV/68378050:_____/09:00335669 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Focal Adhesion Kinase functions as an Akt downstream target in migration of colorectal cancer cells

Original language description

Migration plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the collaboration of Akt, FAK and Src kinases in migration and invasion of colorectal cancer cells. We show that all three kinases can be found in one protein complex but the interaction between Akt and Src is indirect and mediated by FAK. Interestingly, induced Akt signaling causes an increased tyrosine phosphorylation of FAK but this increase is attenuated by Src inhibitor SU6656. We also show that activeAkt stimulates cell migration, but this phenomenon is blocked by FAK knockdown or by inhibition of Src kinase. In addition, all three kinases appeared crucial for successful invasion of colorectal cancer cells. Alltogether, our data suggest the mechanism how the pathway can affect migration of colorectal adenocarcinoma cells. Since FAK acts downstream of Akt, our results imply FAK kinase as a potential key molecule during progression of tumors with active PI3-K/Akt signaling.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Translational Oncology

ISSN

1936-5233

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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