Different effects of the inhibition of Src activity on Akt/PKB in melanoma cells with wild BRAF and mutated BRAF V600E

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10191879" target="_blank" >RIV/00216208:11110/13:10191879 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4236/abc.2013.33A002" target="_blank" >http://dx.doi.org/10.4236/abc.2013.33A002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4236/abc.2013.33A002" target="_blank" >10.4236/abc.2013.33A002</a>

Result language

angličtina

Original language name

Different effects of the inhibition of Src activity on Akt/PKB in melanoma cells with wild BRAF and mutated BRAF V600E

Original language description

Src regulates cell adhesion, invasiveness, motility and growth in cancer cells. In melanoma, accumulating data show that Src inhibition can be effective and may enhance the effects of other agents. Increased Src expression and activity thus has recentlybecome a target for drug therapy. Several melanoma cell lines were exposed to inhibitors of Src activity despite their broad specificity. To examine the particular activity of Src in human melanoma cells, we used SU6656, the selective inhibitor of Src family protein kinases. The activity of Src and cell proliferation were suppressed in HBL human cells, wild type melanoma cells and in SK-MEL-5 human melanoma cells harboring mutant BRAF V600E, upon their treatment with SU6656. The suppression of Src kinase activity had not in- hibitory effects on Akt/PKB activity in SK-MEL-5 cells, which we have previously found in HBL cells. This may indicate that changes of Src involvement in the control of Akt/PKB activity and its downstream signaling

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/NT11231" target="_blank" >NT11231: Control of mTOR and MAPK pathways by Src tyrosine kinase activity - implication for cancer therapy by protein kinase inhibitors</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advances in biological chemistry

ISSN

2162-2183

e-ISSN

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Volume of the periodical

3

Issue of the periodical within the volume

3A

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

6-11

UT code for WoS article

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EID of the result in the Scopus database

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