Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F11%3A00366082" target="_blank" >RIV/68081707:_____/11:00366082 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.cyto.2011.03.013" target="_blank" >http://dx.doi.org/10.1016/j.cyto.2011.03.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cyto.2011.03.013" target="_blank" >10.1016/j.cyto.2011.03.013</a>

Result language

angličtina

Original language name

Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial

Original language description

The resistance of transformed epithelial cells to a detachment-induced apoptosis (anoikis) can significantly affect their susceptibility to anticancer therapy. We showed that detachment of both fetal (FHC) and adenocarcinoma (HT-29) human colon epithelial cells resulted in the activation of the pro-survival Akt pathway, and significant changes in integrin-linked kinase (ILK) and focal adhesive kinase (FAK) phosphorylation. Our results may have important implications for optimization of new strategies intreatment of cancers at different stages of development.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytokine

ISSN

1043-4666

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

34-39

UT code for WoS article

000291916300007

EID of the result in the Scopus database

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