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The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000289" target="_blank" >RIV/00209805:_____/12:#0000289 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.landesbioscience.com/journals/rnabiology/article/20231/?nocache=598305625" target="_blank" >http://www.landesbioscience.com/journals/rnabiology/article/20231/?nocache=598305625</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4161/rna.20231" target="_blank" >10.4161/rna.20231</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells

  • Original language description

    The untranslated regions (UTRs) at the 3' end of mRNA transcripts contain important sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we summarize the information known to date about 3' end processing, sequence characteristics including related binding proteins and the role of 3' UTRs in several selected signaling pathways to delineate their importance in the regulatory processes in mammalian cells. In addition to reviewing recent advances in the more well-known aspects, such as cleavage and polyadenylation processes that influence mRNA stability and location, we concentrate on some newly emerging concepts of the role of the 3' UTR, including alternative polyadenylation sites in relation to proliferation and differentiation and the recognition of the multi-functional properties of noncoding RNAs, including miRNAs that commonly target the 3' UTR. The emerging picture is of a highly complex set of regulatory systems that include autoregulation, cooperati

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    RNA biology

  • ISSN

    1547-6286

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    563-576

  • UT code for WoS article

    000306528800009

  • EID of the result in the Scopus database