The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000289" target="_blank" >RIV/00209805:_____/12:#0000289 - isvavai.cz</a>
Result on the web
<a href="http://www.landesbioscience.com/journals/rnabiology/article/20231/?nocache=598305625" target="_blank" >http://www.landesbioscience.com/journals/rnabiology/article/20231/?nocache=598305625</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4161/rna.20231" target="_blank" >10.4161/rna.20231</a>
Alternative languages
Result language
angličtina
Original language name
The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells
Original language description
The untranslated regions (UTRs) at the 3' end of mRNA transcripts contain important sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we summarize the information known to date about 3' end processing, sequence characteristics including related binding proteins and the role of 3' UTRs in several selected signaling pathways to delineate their importance in the regulatory processes in mammalian cells. In addition to reviewing recent advances in the more well-known aspects, such as cleavage and polyadenylation processes that influence mRNA stability and location, we concentrate on some newly emerging concepts of the role of the 3' UTR, including alternative polyadenylation sites in relation to proliferation and differentiation and the recognition of the multi-functional properties of noncoding RNAs, including miRNAs that commonly target the 3' UTR. The emerging picture is of a highly complex set of regulatory systems that include autoregulation, cooperati
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RNA biology
ISSN
1547-6286
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
563-576
UT code for WoS article
000306528800009
EID of the result in the Scopus database
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