Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F13%3A%230000419" target="_blank" >RIV/00209805:_____/13:#0000419 - isvavai.cz</a>
Result on the web
<a href="http://www.mdpi.com/1422-0067/14/8/15681" target="_blank" >http://www.mdpi.com/1422-0067/14/8/15681</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms140815681" target="_blank" >10.3390/ijms140815681</a>
Alternative languages
Result language
angličtina
Original language name
Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders
Original language description
The biological fate of each mRNA and consequently, the protein to be synthesised, is highly dependent on the nature of the 3´ untranslated region. Despite its non-coding character, the 3' UTR may affect the final mRNA stability, the localisation, the export from the nucleus and the translation efficiency. The conserved regulatory sequences within 3´ UTRs and the specific elements binding to them enable gene expression control at the posttranscriptional level and all these processes reflect the actual state of the cell including proliferation, differentiation, cellular stress or tumourigenesis. Through this article, we briefly outline how the alterations in the establishment and final architecture of 3´ UTRs may contribute to the development of variousdisorders in humans.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
14
Pages from-to
15681-15694
UT code for WoS article
000328501300025
EID of the result in the Scopus database
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