Staufen1 reads out structure and sequence features in ARF1 SBS for specific target recognition

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101765" target="_blank" >RIV/00216224:14740/18:00101765 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Staufen1 reads out structure and sequence features in ARF1 SBS for specific target recognition

Original language description

Most posttranscriptional regulation of gene expression is based on RNA elements in mRNAs recognized by RNA­binding proteins (RBPs). Besides primary sequence elements, a second layer of information is embedded in 3’UTRs of mRNAs in the form of RNA structure. Double­stranded RBPs can bind structures in 3’UTRs and then exert their function based on dsRNA target recognition through a combination of structure and sequence. Staufen1 is a dsRBP involved in mRNA transport and localization, translational control and mRNA decay by a staufen­mediated mRNA decay (SMD) pathway. The Staufen1 binding site (SBS) within human ADP­ribosylation factor1 (ARF1) 3’UTR is one such target and Staufen1 binding to the SBS regulates ARF1 cytoplasmic mRNA levels by the SMD pathway. However, how Staufen1 recognizes specific mRNA targets is still unknown.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA18-08153S" target="_blank" >GA18-08153S: Molecular basis of Staufen-mediated 3'UTR function</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů