Concepts in MDM2 signaling: allosteric regulation and feedback loops
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000290" target="_blank" >RIV/00209805:_____/12:#0000290 - isvavai.cz</a>
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494372/pdf/10.1177_1947601912454140.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494372/pdf/10.1177_1947601912454140.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/1947601912454140" target="_blank" >10.1177/1947601912454140</a>
Alternative languages
Result language
angličtina
Original language name
Concepts in MDM2 signaling: allosteric regulation and feedback loops
Original language description
The function and regulation of MDM2 as a component of a p53-dependent negative feedback loop has formed a core paradigm in the p53 field. This concept, now 20 years old, has been solidified by fields of protein science, transgenic technology, and drug discovery in human cancer. However, it has been noted that a simple negative feedback loop between p53 and MDM2 lacks an intrinsic ?activating? step that counteracts this inhibition and permits oscillation of the feedback to occur as p53 is switched on andoff. More recent work has identified a solution to the missing piece of the picture that counters the negative feedback loop, which is MDM2 itself. Under conditions of genotoxic stress, MDM2 helps to activate p53 by increasing its rate of protein synthesis. This simple observation makes certain aspects of the p53 response more comprehensible such as why MDM2 is upregulated by p53 early on following DNA damage and how phosphorylation of MDM2 at the C-terminal Ser395 by ATM translates int
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genes and cancer
ISSN
1947-6019
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
3-4
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
291-297
UT code for WoS article
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EID of the result in the Scopus database
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