Cancer as a metabolic disease and diabetes as a precancerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000299" target="_blank" >RIV/00209805:_____/12:#0000299 - isvavai.cz</a>
Result on the web
<a href="http://www.linkos.cz/files/klinicka-onkologie/174/4121.pdf" target="_blank" >http://www.linkos.cz/files/klinicka-onkologie/174/4121.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cancer as a metabolic disease and diabetes as a precancerosis
Original language description
The prevailing aerobic glycolysis (so called Warburg effect) in cancer cells is according to current understanding the consequence of reprogramming of cellular metabolism during the process of malignant transformation. Metabolic regulation is inseparablecomponent of cell proliferation machinery and has a tight link with activities of oncogenes and suppressor genes. The purpose of metabolic reprogramming of cancer (but also normal intensively proliferating cells) is to incorporate greater fraction of glucose metabolites into newly synthesised macromolecules. Apart from that, aerobic glycolysis confers several other selective advantages to cancer cells. Epidemiological data indicate that type 2 diabetes mellitus is associated with increased ncidence ofseveral types of cancer and that cancer mortality can be influenced by ertain types of anti-diabetic treatment, however future research is needed to explain whether his relationship might be causal. Deeper knowledge about metabolic proper
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Klinická onkologie
ISSN
0862-495X
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
supplementum 2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
"2S26"-"2S31"
UT code for WoS article
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EID of the result in the Scopus database
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