Mitochondrial Dynamics and Cristae Shape Changes During Metabolic Reprogramming

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00579535" target="_blank" >RIV/67985823:_____/23:00579535 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10472571

Result on the web

<a href="https://doi.org/10.1089/ars.2023.0268" target="_blank" >https://doi.org/10.1089/ars.2023.0268</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/ars.2023.0268" target="_blank" >10.1089/ars.2023.0268</a>

Result language

angličtina

Original language name

Mitochondrial Dynamics and Cristae Shape Changes During Metabolic Reprogramming

Original language description

Significance: The architecture of the mitochondrial network and cristae critically impact cell differentiation and identity. Cells undergoing metabolic reprogramming to aerobic glycolysis (Warburg effect), such as immune cells, stem cells, and cancer cells, go through controlled modifications in mitochondrial architecture, which is critical for achieving the resulting cellular phenotype.Recent Advances: Recent studies in immunometabolism have shown that the manipulation of mitochondrial network dynamics and cristae shape directly affects T cell phenotype and macrophage polarization through altering energy metabolism. Similar manipulations also alter the specific metabolic phenotypes that accompany somatic reprogramming, stem cell differentiation, and cancer cells. The modulation of oxidative phosphorylation activity, accompanied by changes in metabolite signaling, reactive oxygen species generation, and adenosine triphosphate levels, is the shared underlying mechanism.Critical Issues: The plasticity of mitochondrial architecture is particularly vital for metabolic reprogramming. Consequently, failure to adapt the appropriate mitochondrial morphology often compromises the differentiation and identity of the cell. Immune, stem, and tumor cells exhibit striking similarities in their coordination of mitochondrial morphology with metabolic pathways. However, although many general unifying principles can be observed, their validity is not absolute, and the mechanistic links thus need to be further explored.Future Directions: Better knowledge of the molecular mechanisms involved and their relationships to both mitochondrial network and cristae morphology will not only further deepen our understanding of energy metabolism but may also contribute to improved therapeutic manipulation of cell viability, differentiation, proliferation, and identity in many different cell types.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Antioxidants & Redox Signaling

ISSN

1523-0864

e-ISSN

1557-7716

Volume of the periodical

39

Issue of the periodical within the volume

10-12

Country of publishing house

US - UNITED STATES

Number of pages

24

Pages from-to

684-707

UT code for WoS article

001113166100001

EID of the result in the Scopus database

2-s2.0-85167823926